Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents.
BMC Res Notes
; 11(1): 300, 2018 May 15.
Article
in En
| MEDLINE
| ID: mdl-29764479
ABSTRACT
OBJECTIVES:
FTO rs9939609 variant has been shown to be associated with insulin resistance in Caucasian children. However, studies in Asia show inconsistent findings. We investigated the association between FTO rs9939609 polymorphisms and insulin resistance in obese female adolescents in Indonesia, a genetically distinct group within Asia.RESULTS:
A total of 78 obese female adolescents participated in this study. The risk allele (A) frequency of FTO rs9939609 variant in Indonesian obese female adolescence was 44.2%. The frequency of insulin resistance was higher in the subjects with AA (54.6%) or AT (59.6%) than the subject with TT genotype (50%), but did not statistically different (p = 0.81 and p = 0.47, respectively). The insulin resistance rate was also higher in the risk allele (A) than the non-risk allele (T) subjects (0.58 vs. 0.55), but did not statistically different (p = 0.75). There was no association between FTO rs9939609 variant and body mass index, fasting glucose level, fasting insulin level, homeostatic model assessment of insulin resistance, and waist circumference (p > 0.05). In conclusion, FTO rs9939609 variant may not be associated with insulin resistance in Indonesian obese female adolescents. A multicenter study with a larger sample size is needed to clarify these findings.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Pediatric Obesity
/
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Adolescent
/
Child
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
BMC Res Notes
Year:
2018
Document type:
Article
Affiliation country:
Indonesia