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Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.
de Witte, Wilhelmus E A; Rottschäfer, Vivi; Danhof, Meindert; van der Graaf, Piet H; Peletier, Lambertus A; de Lange, Elizabeth C M.
Affiliation
  • de Witte WEA; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC, Leiden, The Netherlands.
  • Rottschäfer V; Mathematical Institute, Leiden University, 2333 CA, Leiden, The Netherlands.
  • Danhof M; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC, Leiden, The Netherlands.
  • van der Graaf PH; Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC, Leiden, The Netherlands.
  • Peletier LA; Certara Quantitative Systems Pharmacology, Canterbury Innovation Centre, Canterbury, CT2 7FG, UK.
  • de Lange ECM; Mathematical Institute, Leiden University, 2333 CA, Leiden, The Netherlands.
J Pharmacokinet Pharmacodyn ; 45(4): 621-635, 2018 08.
Article in En | MEDLINE | ID: mdl-29777407
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morphine Limits: Animals Language: En Journal: J Pharmacokinet Pharmacodyn Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: Países Bajos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morphine Limits: Animals Language: En Journal: J Pharmacokinet Pharmacodyn Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: Países Bajos Country of publication: Estados Unidos