Superselective intraarterial cerebral infusion of cetuximab with blood brain barrier disruption combined with Stupp Protocol for newly diagnosed glioblastoma.
J Exp Ther Oncol
; 12(3): 223-229, 2018 May.
Article
in En
| MEDLINE
| ID: mdl-29790314
ABSTRACT
OBJECTIVE:
We describe the first case of a novel treatment for a newly diagnosed glioblastoma (GBM) using superselective intraarterial cerebral infusion (SIACI) of cetuximab after osmotic disruption of the blood-brain barrier (BBB) with mannitol. A 51year-old female underwent craniotomy for removal of a right frontal GBM. Pathology confirmed EGFR amplification, and she underwent three treatments of SIACI of cetuximab to the tumor site. The first treatment was given within a week of starting standard of care chemoradiation (Stupp protocol), which is a combination of radiation treatment (2 Gy per/ day x 30 days, total of 60 Gy) and oral temozolomide (75 mg/m2). The second and third SIACI of cetuximab were administered 3 and 6 months later, while the patient continued on maintenance temozolomide. Post-radiation changes on MRI were stable, and there were no signs of recurrence at 4 and 6 months post-resection. Herein, we detail the technical aspects of this novel treatment paradigm and suggest that SIACI of cetuximab after BBB disruption using mannitol, combined with the standard of care chemoradiation therapy, may be an effective treatment method for newly diagnosed EGFR amplified glioblastoma.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Blood-Brain Barrier
/
Glioblastoma
/
Antineoplastic Agents, Alkylating
/
Dose Fractionation, Radiation
/
Dacarbazine
/
Cetuximab
/
Antineoplastic Agents, Immunological
/
Mannitol
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
J Exp Ther Oncol
Journal subject:
NEOPLASIAS
/
TERAPIA POR MEDICAMENTOS
Year:
2018
Document type:
Article
Affiliation country:
Estados Unidos