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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Walton, Zandra E; Patel, Chirag H; Brooks, Rebekah C; Yu, Yongjun; Ibrahim-Hashim, Arig; Riddle, Malini; Porcu, Alessandra; Jiang, Tianying; Ecker, Brett L; Tameire, Feven; Koumenis, Constantinos; Weeraratna, Ashani T; Welsh, David K; Gillies, Robert; Alwine, James C; Zhang, Lin; Powell, Jonathan D; Dang, Chi V.
Affiliation
  • Walton ZE; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: zandrawalton@alumni.upenn.edu.
  • Patel CH; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Brooks RC; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Yu Y; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Ibrahim-Hashim A; Department of Cancer Physiology and Department of Radiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
  • Riddle M; Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.
  • Porcu A; Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.
  • Jiang T; The Wistar Institute, Philadelphia, PA 19104, USA.
  • Ecker BL; The Wistar Institute, Philadelphia, PA 19104, USA; Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Tameire F; Department of Radiation Oncology, Perelman University School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Koumenis C; Department of Radiation Oncology, Perelman University School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Weeraratna AT; The Wistar Institute, Philadelphia, PA 19104, USA.
  • Welsh DK; Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92093, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.
  • Gillies R; Department of Cancer Physiology and Department of Radiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
  • Alwine JC; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Zhang L; Center for Research on Reproduction & Women's Health, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Powell JD; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Sidney-Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  • Dang CV; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Wistar Institute, Philadelphia, PA 19104, USA; Ludwig Institute for Cancer Research, New York, NY 10017, USA. Electronic address: cdang@licr.org.
Cell ; 174(1): 72-87.e32, 2018 06 28.
Article in En | MEDLINE | ID: mdl-29861175
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Hypoxia / Circadian Clocks / Mechanistic Target of Rapamycin Complex 1 Type of study: Prognostic_studies Language: En Journal: Cell Year: 2018 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Hypoxia / Circadian Clocks / Mechanistic Target of Rapamycin Complex 1 Type of study: Prognostic_studies Language: En Journal: Cell Year: 2018 Document type: Article Country of publication: Estados Unidos