[Progress of study on changes of mitochondrial and its role in obstructive sleep apnea hypopnea syndrome].

ABSTRACT

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common respiratory disease which has become an important public health problem. A high prevalence of OSAHS in the elderly may suggest that aging could be considered as a risk factor for the development of OSAHS. Recent work that has advanced understanding of mutations accumulating over time in the mitochondrial DNA (mtDNA) has been closely associated with aging. More and more researchers pay attention to changes of mitochondria morphology, electron transport chain enzymes and mtDNA. The process research of accumulation of circular mtDNA bearing deletions or mtDNA with accumulated point mutations in OSAHS subjects might be able to make mitochondrial become a representative biomarker for adverse outcomes from oxidative stress and cardiovascular diseases in the future.