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YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.
Fan, Pang-Dian; Narzisi, Giuseppe; Jayaprakash, Anitha D; Venturini, Elisa; Robine, Nicolas; Smibert, Peter; Germer, Soren; Yu, Helena A; Jordan, Emmet J; Paik, Paul K; Janjigian, Yelena Y; Chaft, Jamie E; Wang, Lu; Jungbluth, Achim A; Middha, Sumit; Spraggon, Lee; Qiao, Huan; Lovly, Christine M; Kris, Mark G; Riely, Gregory J; Politi, Katerina; Varmus, Harold; Ladanyi, Marc.
Affiliation
  • Fan PD; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065; fanp@mskcc.org varmus@med.cornell.edu ladanyim@mskcc.org.
  • Narzisi G; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Jayaprakash AD; Computational Biology, New York Genome Center, New York, NY 10013.
  • Venturini E; Technology Innovation Lab, New York Genome Center, New York, NY 10013.
  • Robine N; Project Management, New York Genome Center, New York, NY 10013.
  • Smibert P; Computational Biology, New York Genome Center, New York, NY 10013.
  • Germer S; Technology Innovation Lab, New York Genome Center, New York, NY 10013.
  • Yu HA; Sequencing Operations, New York Genome Center, New York, NY 10013.
  • Jordan EJ; Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Paik PK; Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Janjigian YY; Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Chaft JE; Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Wang L; Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Jungbluth AA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Middha S; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Spraggon L; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Qiao H; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Lovly CM; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Kris MG; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232.
  • Riely GJ; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232.
  • Politi K; Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Varmus H; Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Ladanyi M; Department of Pathology and the Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520.
Proc Natl Acad Sci U S A ; 115(26): E6030-E6038, 2018 06 26.
Article in En | MEDLINE | ID: mdl-29875142
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Transposable Elements / Gene Expression Regulation, Neoplastic / Gene Amplification / Drug Resistance, Neoplasm / Enzyme Inhibitors / Proto-Oncogene Proteins c-yes / ErbB Receptors / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Transposable Elements / Gene Expression Regulation, Neoplastic / Gene Amplification / Drug Resistance, Neoplasm / Enzyme Inhibitors / Proto-Oncogene Proteins c-yes / ErbB Receptors / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: Estados Unidos