Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention.

Baptiste, Beverly A; Katchur, Steven R; Fivenson, Elayne M; Croteau, Deborah L; Rumsey, William L; Bohr, Vilhelm A

Baptiste, Beverly A; Katchur, Steven R; Fivenson, Elayne M; Croteau, Deborah L; Rumsey, William L; Bohr, Vilhelm A.

Affiliation

Baptiste BA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Katchur SR; Respiratory Therapy Area, GSK R&D, Collegeville, PA, United States.
Fivenson EM; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Croteau DL; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Rumsey WL; Respiratory Therapy Area, GSK R&D, Collegeville, PA, United States.
Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States. Electronic address: BohrV@grc.nia.nih.gov.

Free Radic Biol Med ; 124: 149-162, 2018 08 20.

Article in En | MEDLINE | ID: mdl-29879444

Subject(s)
Key words

8-Oxoguanine DNA glycosylase-1; 8-dihydroguanine; 8-oxo-7; Base excision repair; Mitochondria; OGG1(S326C); Oxidative stress

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / DNA, Mitochondrial / DNA Glycosylases / DNA Repair / Small Molecule Libraries / Mitochondria Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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