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Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-ß2 to promote chemoresistance in colorectal cancer.
Tang, Yen-An; Chen, Yu-Feng; Bao, Yi; Mahara, Sylvia; Yatim, Siti Maryam J M; Oguz, Gokce; Lee, Puay Leng; Feng, Min; Cai, Yu; Tan, Ern Yu; Fong, Sau Shung; Yang, Zi-Huan; Lan, Ping; Wu, Xiao-Jian; Yu, Qiang.
Affiliation
  • Tang YA; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672.
  • Chen YF; Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
  • Bao Y; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
  • Mahara S; Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
  • Yatim SMJM; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672.
  • Oguz G; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672.
  • Lee PL; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672.
  • Feng M; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672.
  • Cai Y; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672.
  • Tan EY; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore 138672.
  • Fong SS; School of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Yang ZH; Cancer Research Institute, Jinan University, Guangzhou 510632, China.
  • Lan P; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433.
  • Wu XJ; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433.
  • Yu Q; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Proc Natl Acad Sci U S A ; 115(26): E5990-E5999, 2018 06 26.
Article in En | MEDLINE | ID: mdl-29891662
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Colorectal Neoplasms / Gene Expression Regulation, Neoplastic / Drug Resistance, Neoplasm / Hypoxia-Inducible Factor 1, alpha Subunit / Transforming Growth Factor beta2 / Tumor Microenvironment / Zinc Finger Protein Gli2 / Neoplasm Proteins Limits: Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Colorectal Neoplasms / Gene Expression Regulation, Neoplastic / Drug Resistance, Neoplasm / Hypoxia-Inducible Factor 1, alpha Subunit / Transforming Growth Factor beta2 / Tumor Microenvironment / Zinc Finger Protein Gli2 / Neoplasm Proteins Limits: Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: Estados Unidos