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Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells.
Silva, Viviane A O; Rosa, Marcela N; Miranda-Gonçalves, Vera; Costa, Angela M; Tansini, Aline; Evangelista, Adriane F; Martinho, Olga; Carloni, Adriana C; Jones, Chris; Lima, João Paulo; Pianowski, Luiz F; Reis, Rui Manuel.
Affiliation
  • Silva VAO; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.
  • Rosa MN; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.
  • Miranda-Gonçalves V; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.
  • Costa AM; ICVS/3B's - PT Government Associate Laboratory, 4806-909, Braga, Guimarães, Portugal.
  • Tansini A; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.
  • Evangelista AF; ICVS/3B's - PT Government Associate Laboratory, 4806-909, Braga, Guimarães, Portugal.
  • Martinho O; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.
  • Carloni AC; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.
  • Jones C; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.
  • Lima JP; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.
  • Pianowski LF; ICVS/3B's - PT Government Associate Laboratory, 4806-909, Braga, Guimarães, Portugal.
  • Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.
Invest New Drugs ; 37(2): 223-237, 2019 04.
Article in En | MEDLINE | ID: mdl-29931585
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Glioblastoma / Drug Resistance, Neoplasm / Euphorbia / Drug Synergism / Temozolomide / Lanosterol Type of study: Prognostic_studies Limits: Humans Language: En Journal: Invest New Drugs Year: 2019 Document type: Article Affiliation country: Brasil
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Glioblastoma / Drug Resistance, Neoplasm / Euphorbia / Drug Synergism / Temozolomide / Lanosterol Type of study: Prognostic_studies Limits: Humans Language: En Journal: Invest New Drugs Year: 2019 Document type: Article Affiliation country: Brasil