[Immunotherapy in lung cancer: New concepts]. / Immunothérapie et cancer du poumon : nouveaux concepts.
Rev Mal Respir
; 35(6): 642-651, 2018 Jun.
Article
in Fr
| MEDLINE
| ID: mdl-29941206
ABSTRACT
Improvements in knowledge about the complexity of the tumor microenvironment have paved the way for a revolution in lung cancer treatment with the emergence of immune checkpoint inhibitors. The immune checkpoints negatively regulate immune cells and lead to a dormant state the immune cells are then unable to interact effectively with their targets. The immune checkpoint inhibitors are monoclonal antibodies that block immune checkpoints and permit reactivation of the immune response against the tumor. Although immune checkpoint inhibitors are effective as monotherapy, several other immune targets exist. The better understanding of the involvement of these new targets in the immune response against tumors is leading to the design of new compounds and new therapeutic approaches.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunotherapy
/
Lung Neoplasms
/
Medical Oncology
Limits:
Humans
Language:
Fr
Journal:
Rev Mal Respir
Year:
2018
Document type:
Article
Affiliation country:
Francia