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Acute electrophysiologic effects of the polyphenols resveratrol and piceatannol in rabbit atria.
Frommeyer, Gerrit; Wolfes, Julian; Ellermann, Christian; Kochhäuser, Simon; Dechering, Dirk G; Eckardt, Lars.
Affiliation
  • Frommeyer G; Clinic for Cardiology II - Electrophysiology, University Hospital of Münster, Münster, Germany.
  • Wolfes J; Clinic for Cardiology II - Electrophysiology, University Hospital of Münster, Münster, Germany.
  • Ellermann C; Clinic for Cardiology II - Electrophysiology, University Hospital of Münster, Münster, Germany.
  • Kochhäuser S; Clinic for Cardiology II - Electrophysiology, University Hospital of Münster, Münster, Germany.
  • Dechering DG; Clinic for Cardiology II - Electrophysiology, University Hospital of Münster, Münster, Germany.
  • Eckardt L; Clinic for Cardiology II - Electrophysiology, University Hospital of Münster, Münster, Germany.
Clin Exp Pharmacol Physiol ; 46(1): 94-98, 2019 01.
Article in En | MEDLINE | ID: mdl-29956844
ABSTRACT
The natural polyphenol resveratrol and its analogue piceatannol have various beneficial effects including antiarrhythmic properties. The aim of the present study was to examine potential electrophysiologic effects in an experimental whole-heart model of atrial fibrillation (AF). Simultaneous infusion of resveratrol (50 µmol/L) or piceatannol (10 µmol/L) in rabbit hearts resulted in an increase in atrial refractory period. Both agents induced a significant slowing of atrial conduction and of intrinsic heart rate. In both groups, a trend toward a reduction in AF and a regularization of AF was observed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Atrial Function / Electrophysiological Phenomena / Resveratrol / Heart Atria Limits: Animals Language: En Journal: Clin Exp Pharmacol Physiol Year: 2019 Document type: Article Affiliation country: Alemania
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Atrial Function / Electrophysiological Phenomena / Resveratrol / Heart Atria Limits: Animals Language: En Journal: Clin Exp Pharmacol Physiol Year: 2019 Document type: Article Affiliation country: Alemania