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Adaptation and conservation insights from the koala genome.
Johnson, Rebecca N; O'Meally, Denis; Chen, Zhiliang; Etherington, Graham J; Ho, Simon Y W; Nash, Will J; Grueber, Catherine E; Cheng, Yuanyuan; Whittington, Camilla M; Dennison, Siobhan; Peel, Emma; Haerty, Wilfried; O'Neill, Rachel J; Colgan, Don; Russell, Tonia L; Alquezar-Planas, David E; Attenbrow, Val; Bragg, Jason G; Brandies, Parice A; Chong, Amanda Yoon-Yee; Deakin, Janine E; Di Palma, Federica; Duda, Zachary; Eldridge, Mark D B; Ewart, Kyle M; Hogg, Carolyn J; Frankham, Greta J; Georges, Arthur; Gillett, Amber K; Govendir, Merran; Greenwood, Alex D; Hayakawa, Takashi; Helgen, Kristofer M; Hobbs, Matthew; Holleley, Clare E; Heider, Thomas N; Jones, Elizabeth A; King, Andrew; Madden, Danielle; Graves, Jennifer A Marshall; Morris, Katrina M; Neaves, Linda E; Patel, Hardip R; Polkinghorne, Adam; Renfree, Marilyn B; Robin, Charles; Salinas, Ryan; Tsangaras, Kyriakos; Waters, Paul D; Waters, Shafagh A.
Affiliation
  • Johnson RN; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia. rebecca.johnson@austmus.gov.au.
  • O'Meally D; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia. rebecca.johnson@austmus.gov.au.
  • Chen Z; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Etherington GJ; Animal Research Centre, Faculty of Science, Health, Education & Engineering, University of the Sunshine Coast, Maroochydore, Queensland, Australia.
  • Ho SYW; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.
  • Nash WJ; Earlham Institute, Norwich Research Park, Norwich, UK.
  • Grueber CE; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Cheng Y; Earlham Institute, Norwich Research Park, Norwich, UK.
  • Whittington CM; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Dennison S; San Diego Zoo Global, San Diego, CA, USA.
  • Peel E; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Haerty W; UQ Genomics Initiative, University of Queensland, St Lucia, Queensland, Australia.
  • O'Neill RJ; Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Colgan D; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Russell TL; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Alquezar-Planas DE; Earlham Institute, Norwich Research Park, Norwich, UK.
  • Attenbrow V; Department of Molecular and Cell Biology and Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
  • Bragg JG; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Brandies PA; Ramaciotti Centre for Genomics, University of New South Wales, Kensington, New South Wales, Australia.
  • Chong AY; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Deakin JE; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Di Palma F; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
  • Duda Z; National Herbarium of New South Wales, Royal Botanic Gardens & Domain Trust, Sydney, New South Wales, Australia.
  • Eldridge MDB; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Ewart KM; Earlham Institute, Norwich Research Park, Norwich, UK.
  • Hogg CJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Frankham GJ; Institute for Applied Ecology, University of Canberra, Bruce, Australian Capital Territory, Australia.
  • Georges A; Earlham Institute, Norwich Research Park, Norwich, UK.
  • Gillett AK; Department of Biological Sciences, University of East Anglia, Norwich, UK.
  • Govendir M; Department of Molecular and Cell Biology and Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
  • Greenwood AD; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Hayakawa T; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Helgen KM; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Hobbs M; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Holleley CE; Institute for Applied Ecology, University of Canberra, Bruce, Australian Capital Territory, Australia.
  • Heider TN; Australia Zoo Wildlife Hospital, Beerwah, Queensland, Australia.
  • Jones EA; Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • King A; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
  • Madden D; Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
  • Graves JAM; Department of Wildlife Science (Nagoya Railroad Co., Ltd.), Primate Research Institute, Kyoto University, Inuyama, Japan.
  • Morris KM; Japan Monkey Centre, Inuyama, Japan.
  • Neaves LE; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Patel HR; School of Biological Sciences, Environment Institute, Centre for Applied Conservation Science, and ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, South Australia, Australia.
  • Polkinghorne A; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Renfree MB; Australian National Wildlife Collection, National Research Collections Australia, CSIRO, Canberra, Australian Capital Territory, Australia.
  • Robin C; Department of Molecular and Cell Biology and Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
  • Salinas R; Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
  • Tsangaras K; Australian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
  • Waters PD; Animal Research Centre, Faculty of Science, Health, Education & Engineering, University of the Sunshine Coast, Maroochydore, Queensland, Australia.
  • Waters SA; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
Nat Genet ; 50(8): 1102-1111, 2018 08.
Article in En | MEDLINE | ID: mdl-29967444
ABSTRACT
The koala, the only extant species of the marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala's ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala's survival in the wild.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptation, Physiological / Phascolarctidae Type of study: Prognostic_studies Limits: Animals Country/Region as subject: Oceania Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2018 Document type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptation, Physiological / Phascolarctidae Type of study: Prognostic_studies Limits: Animals Country/Region as subject: Oceania Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2018 Document type: Article Affiliation country: Australia