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Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease.
Kim, Donghoon; Yoo, Je Min; Hwang, Heehong; Lee, Junghee; Lee, Su Hyun; Yun, Seung Pil; Park, Myung Jin; Lee, MinJun; Choi, Seulah; Kwon, Sang Ho; Lee, Saebom; Kwon, Seung-Hwan; Kim, Sangjune; Park, Yong Joo; Kinoshita, Misaki; Lee, Young-Ho; Shin, Seokmin; Paik, Seung R; Lee, Sung Joong; Lee, Seulki; Hong, Byung Hee; Ko, Han Seok.
Affiliation
  • Kim D; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Yoo JM; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hwang H; Department of Chemistry, College of Natural Science, Seoul National University, Seoul, Republic of Korea.
  • Lee J; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lee SH; Department of Neuroscience and Physiology, Interdisciplinary Program in Neuroscience, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
  • Yun SP; Inter-University Semiconductor Research Centre, Seoul National University, Seoul, Republic of Korea.
  • Park MJ; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lee M; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Choi S; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kwon SH; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lee S; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA, USA.
  • Kwon SH; Department of Chemistry, College of Natural Science, Seoul National University, Seoul, Republic of Korea.
  • Kim S; Department of Chemistry, College of Natural Science, Seoul National University, Seoul, Republic of Korea.
  • Park YJ; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kinoshita M; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lee YH; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Shin S; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Paik SR; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lee SJ; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lee S; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hong BH; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Ko HS; The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nat Nanotechnol ; 13(9): 812-818, 2018 09.
Article in En | MEDLINE | ID: mdl-29988049
ABSTRACT
Though emerging evidence indicates that the pathogenesis of Parkinson's disease is strongly correlated to the accumulation1,2 and transmission3,4 of α-synuclein (α-syn) aggregates in the midbrain, no anti-aggregation agents have been successful at treating the disease in the clinic. Here, we show that graphene quantum dots (GQDs) inhibit fibrillization of α-syn and interact directly with mature fibrils, triggering their disaggregation. Moreover, GQDs can rescue neuronal death and synaptic loss, reduce Lewy body and Lewy neurite formation, ameliorate mitochondrial dysfunctions, and prevent neuron-to-neuron transmission of α-syn pathology provoked by α-syn preformed fibrils5,6. We observe, in vivo, that GQDs penetrate the blood-brain barrier and protect against dopamine neuron loss induced by α-syn preformed fibrils, Lewy body/Lewy neurite pathology and behavioural deficits.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Blood-Brain Barrier / Quantum Dots / Alpha-Synuclein / Protein Aggregation, Pathological / Graphite Limits: Animals / Humans Language: En Journal: Nat Nanotechnol Year: 2018 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Blood-Brain Barrier / Quantum Dots / Alpha-Synuclein / Protein Aggregation, Pathological / Graphite Limits: Animals / Humans Language: En Journal: Nat Nanotechnol Year: 2018 Document type: Article Affiliation country: Estados Unidos