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Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle.
McShan, Andrew C; Natarajan, Kannan; Kumirov, Vlad K; Flores-Solis, David; Jiang, Jiansheng; Badstübner, Mareike; Toor, Jugmohit S; Bagshaw, Clive R; Kovrigin, Evgenii L; Margulies, David H; Sgourakis, Nikolaos G.
Affiliation
  • McShan AC; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Natarajan K; Molecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA, USA.
  • Kumirov VK; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Flores-Solis D; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Jiang J; Molecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA, USA.
  • Badstübner M; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Toor JS; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Bagshaw CR; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA.
  • Kovrigin EL; Department of Chemistry, Marquette University, Milwaukee, WI, USA.
  • Margulies DH; Molecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA, USA.
  • Sgourakis NG; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA. nsgourak@ucsc.edu.
Nat Chem Biol ; 14(8): 811-820, 2018 08.
Article in En | MEDLINE | ID: mdl-29988068
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Immunoglobulins / Histocompatibility Antigens Class I / Allosteric Regulation / Membrane Proteins Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Immunoglobulins / Histocompatibility Antigens Class I / Allosteric Regulation / Membrane Proteins Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos