Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy.
Int J Mol Sci
; 19(7)2018 Jul 14.
Article
in En
| MEDLINE
| ID: mdl-30011933
ABSTRACT
γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers-glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma-and promotes cancer progression; its depletion leads to the suppression of proliferation, invasion, and migration of cancer cells. It has been demonstrated that the suppression or inhibition of GGCT has an antitumor effect in cancer-bearing xenograft mice. Based on these observations, GGCT is now recognized as a promising therapeutic target in various cancers. This review summarizes recent advances on the mechanisms of the antitumor activity of GGCT inhibition.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alanine
/
Enzyme Inhibitors
/
Molecular Targeted Therapy
/
Gamma-Glutamylcyclotransferase
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2018
Document type:
Article
Affiliation country:
Japón