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Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) ß Inhibitor.
Chandrasekhar, Jayaraman; Dick, Ryan; Van Veldhuizen, Joshua; Koditek, David; Lepist, Eve-Irene; McGrath, Mary E; Patel, Leena; Phillips, Gary; Sedillo, Kassandra; Somoza, John R; Therrien, Joseph; Till, Nicholas A; Treiberg, Jennifer; Villaseñor, Armando G; Zherebina, Yelena; Perreault, Stephane.
Affiliation
  • Chandrasekhar J; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
  • Dick R; Gilead Sciences, Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States.
  • Van Veldhuizen J; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
  • Koditek D; Gilead Sciences, Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States.
  • McGrath ME; Gilead Sciences, Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States.
  • Patel L; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
  • Phillips G; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
  • Sedillo K; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
  • Somoza JR; Gilead Sciences, Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States.
  • Therrien J; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
  • Treiberg J; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
  • Villaseñor AG; Gilead Sciences, Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States.
  • Zherebina Y; Gilead Sciences, Inc. , 333 Lakeside Drive , Foster City , California 94404 , United States.
  • Perreault S; Gilead Sciences, Inc. , 199 East Blaine Street , Seattle , Washington 98102 , United States.
J Med Chem ; 61(15): 6858-6868, 2018 Aug 09.
Article in En | MEDLINE | ID: mdl-30015489
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Enzyme Inhibitors / Phosphoinositide-3 Kinase Inhibitors Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Enzyme Inhibitors / Phosphoinositide-3 Kinase Inhibitors Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Estados Unidos