Estimating the contribution of folding stability to nonspecific epistasis in protein evolution.
Proteins
; 86(12): 1242-1250, 2018 12.
Article
in En
| MEDLINE
| ID: mdl-30039542
ABSTRACT
The extent of nonadditive interaction among mutations or epistasis reflects the ruggedness of the fitness landscape, the mapping of genotype to reproductive fitness. In protein evolution, there is strong support for the importance and prevalence of epistasis but the quantitative and relative contribution of various factors to epistasis are poorly known. Here, we determine the contribution of selection for folding stability to epistasis in protein evolution. By combining theoretical estimates of the rates of molecular evolution and the nonlinear mapping between protein folding thermodynamics and fitness, we show that the simple selection for folding stability imposes at least ~30% to ~40% epistasis in long-term protein evolution. Estimating the contribution of governing factors in molecular evolution such as protein folding stability to epistasis will provide a better understanding of epistasis that could improve methods in molecular evolution.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
/
Evolution, Molecular
/
Epistasis, Genetic
/
Models, Biological
Type of study:
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
Proteins
Journal subject:
BIOQUIMICA
Year:
2018
Document type:
Article
Affiliation country:
Canadá