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NF-κB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
Lacher, Sonja M; Thurm, Christoph; Distler, Ute; Mohebiany, Alma N; Israel, Nicole; Kitic, Maja; Ebering, Anna; Tang, Yilang; Klein, Matthias; Wabnitz, Guido H; Wanke, Florian; Samstag, Yvonne; Bopp, Tobias; Kurschus, Florian C; Simeoni, Luca; Tenzer, Stefan; Waisman, Ari.
Affiliation
  • Lacher SM; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Thurm C; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology, and Inflammation, Otto von Guericke University, Magdeburg, Germany.
  • Distler U; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.
  • Mohebiany AN; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Israel N; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Kitic M; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Ebering A; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Tang Y; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Klein M; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.
  • Wabnitz GH; Institute of Immunology, Section Molecular Immunology, Ruprecht-Karls-University, Heidelberg, Germany.
  • Wanke F; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Samstag Y; Institute of Immunology, Section Molecular Immunology, Ruprecht-Karls-University, Heidelberg, Germany.
  • Bopp T; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.
  • Kurschus FC; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Simeoni L; Institute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology, and Inflammation, Otto von Guericke University, Magdeburg, Germany.
  • Tenzer S; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.
  • Waisman A; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. Electronic address: Waisman@uni-mainz.de.
J Autoimmun ; 94: 110-121, 2018 11.
Article in En | MEDLINE | ID: mdl-30061013
Subject(s)
Actins/immunology; Encephalomyelitis, Autoimmune, Experimental/immunology; Lymphocyte Activation; Protein Serine-Threonine Kinases/immunology; Receptors, Antigen, T-Cell/immunology; T-Lymphocytes/immunology; Actins/genetics; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/immunology; Animals; Central Nervous System/immunology; Central Nervous System/pathology; Encephalomyelitis, Autoimmune, Experimental/chemically induced; Encephalomyelitis, Autoimmune, Experimental/genetics; Encephalomyelitis, Autoimmune, Experimental/pathology; Gene Expression Profiling; Gene Expression Regulation; Lymph Nodes/immunology; Lymph Nodes/pathology; Membrane Proteins/genetics; Membrane Proteins/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/immunology; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/immunology; Myelin-Oligodendrocyte Glycoprotein/administration & dosage; Peptide Fragments/administration & dosage; Phospholipase C gamma/genetics; Phospholipase C gamma/immunology; Phosphoproteins/genetics; Phosphoproteins/immunology; Primary Cell Culture; Protein Serine-Threonine Kinases/deficiency; Protein Serine-Threonine Kinases/genetics; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/immunology; Receptors, Antigen, T-Cell/genetics; Signal Transduction; Spleen/immunology; Spleen/pathology; T-Box Domain Proteins/genetics; T-Box Domain Proteins/immunology; T-Lymphocytes/pathology; ZAP-70 Protein-Tyrosine Kinase/genetics; ZAP-70 Protein-Tyrosine Kinase/immunology; NF-kappaB-Inducing Kinase
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / Receptors, Antigen, T-Cell / T-Lymphocytes / Actins / Protein Serine-Threonine Kinases / Encephalomyelitis, Autoimmune, Experimental Language: En Journal: J Autoimmun Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / Receptors, Antigen, T-Cell / T-Lymphocytes / Actins / Protein Serine-Threonine Kinases / Encephalomyelitis, Autoimmune, Experimental Language: En Journal: J Autoimmun Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: Alemania Country of publication: Reino Unido