Multicarbazole scaffolds for selective G-quadruplex binding.
Chem Commun (Camb)
; 54(69): 9647-9650, 2018 Aug 23.
Article
in En
| MEDLINE
| ID: mdl-30101241
ABSTRACT
Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2018
Document type:
Article
Affiliation country:
Australia