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Development of 2-aminooxazoline 3-azaxanthene ß-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Low, Jonathan D; Bartberger, Michael D; Chen, Kui; Cheng, Yuan; Fielden, Mark R; Gore, Vijay; Hickman, Dean; Liu, Qingyian; Allen Sickmier, E; Vargas, Hugo M; Werner, Jonathan; White, Ryan D; Whittington, Douglas A; Wood, Stephen; Minatti, Ana E.
Affiliation
  • Low JD; Department of Medicinal Chemistry , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA . Email: aminatti@amgen.com ; Tel: +1 805 447 4721.
  • Bartberger MD; Department of Molecular Engineering , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
  • Chen K; Department Discovery Technologies , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
  • Cheng Y; Department of Medicinal Chemistry , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA . Email: aminatti@amgen.com ; Tel: +1 805 447 4721.
  • Fielden MR; Comparative Biology and Safety Sciences , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
  • Gore V; Department of Medicinal Chemistry , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA . Email: aminatti@amgen.com ; Tel: +1 805 447 4721.
  • Hickman D; Department of Pharmacokinetics and Drug Metabolism , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
  • Liu Q; Department of Medicinal Chemistry , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA . Email: aminatti@amgen.com ; Tel: +1 805 447 4721.
  • Allen Sickmier E; Department of Molecular Engineering , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA.
  • Vargas HM; Comparative Biology and Safety Sciences , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
  • Werner J; Comparative Biology and Safety Sciences , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
  • White RD; Department of Medicinal Chemistry , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA.
  • Whittington DA; Department of Molecular Engineering , Amgen Inc. , 360 Binney Street , Cambridge , MA 02142 , USA.
  • Wood S; Department of Neuroscience , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA.
  • Minatti AE; Department of Medicinal Chemistry , Amgen Inc. , One Amgen Center Drive , Thousand Oaks , CA 91320 , USA . Email: aminatti@amgen.com ; Tel: +1 805 447 4721.
Medchemcomm ; 8(6): 1196-1206, 2017 Jun 01.
Article in En | MEDLINE | ID: mdl-30108829
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Medchemcomm Year: 2017 Document type: Article Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Medchemcomm Year: 2017 Document type: Article Country of publication: Reino Unido