Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.
Matrix Biol
; 75-76: 1-11, 2019 01.
Article
in En
| MEDLINE
| ID: mdl-30130584
ABSTRACT
The overall structure and architecture of the extracellular matrix undergo dramatic alterations in composition, form, and functionality over time. The stochasticity begins during development, essential for maintaining organismal homeostasis and is heavily implicated in many pathobiological states including fibrosis and cancer. Modeling and remodeling of the matrix is driven by the local cellular milieu and secreted and cell-associated components in a framework of dynamic reciprocity. This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Extracellular Matrix Proteins
/
Extracellular Matrix
/
Homeostasis
Limits:
Humans
Language:
En
Journal:
Matrix Biol
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2019
Document type:
Article