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TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation.
Kato, Sota; Takayama, Noriko; Takano, Hiroki; Koretsune, Hiroko; Koizumi, Chie; Kunioka, Ei-Ichi; Uchida, Saeko; Takahashi, Teisuke; Yamamoto, Koji.
Affiliation
  • Kato S; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. Electronic address: so-katou@taisho.co.jp.
  • Takayama N; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Takano H; Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
  • Koretsune H; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Koizumi C; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Kunioka EI; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Uchida S; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Takahashi T; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Yamamoto K; Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Eur J Pharmacol ; 838: 138-144, 2018 Nov 05.
Article in En | MEDLINE | ID: mdl-30179610
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Dihydropyridines / Erythropoietin / Enzyme Inhibitors / Renal Insufficiency, Chronic / Hypoxia-Inducible Factor-Proline Dioxygenases / Hematinics / Anemia Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Pharmacol Year: 2018 Document type: Article Country of publication: Países Bajos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Dihydropyridines / Erythropoietin / Enzyme Inhibitors / Renal Insufficiency, Chronic / Hypoxia-Inducible Factor-Proline Dioxygenases / Hematinics / Anemia Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Pharmacol Year: 2018 Document type: Article Country of publication: Países Bajos