Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-&#954;B directly regulates PUMA-dependent apoptosis.

Sun, Li; Huang, Yuan; Liu, Yeying; Zhao, Yujie; He, Xiaoxiao; Zhang, Lingling; Wang, Feng; Zhang, Yingjie

Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis.

Sun, Li; Huang, Yuan; Liu, Yeying; Zhao, Yujie; He, Xiaoxiao; Zhang, Lingling; Wang, Feng; Zhang, Yingjie.

Affiliation

Sun L; College of Biology, Hunan University, Changsha, 410082, China.
Huang Y; Department of Out-patient, Affiliated Hospital of Hebei University of Engineering, Handan, 056002, China.
Liu Y; College of Biology, Hunan University, Changsha, 410082, China.
Zhao Y; College of Biology, Hunan University, Changsha, 410082, China.
He X; College of Biology, Hunan University, Changsha, 410082, China.
Zhang L; College of Biology, Hunan University, Changsha, 410082, China.
Wang F; Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha, 410013, China. zhll0807@csu.edu.cn.
Zhang Y; Department of Gastroenterology, The Tenth People's Hospital of Shanghai, Tongji University, Shanghai, 200072, China. wolffeng2000@hotmail.com.

Cell Death Dis ; 9(9): 911, 2018 09 05.

Article in En | MEDLINE | ID: mdl-30185800

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-kappa B / Proto-Oncogene Proteins / Apoptosis / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-akt / Apoptosis Regulatory Proteins / Forkhead Box Protein O3 Limits: Animals / Female / Humans Language: En Journal: Cell Death Dis Year: 2018 Document type: Article Affiliation country: China

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