Fish consumption and risk of depression: Epidemiological evidence from prospective studies.
Asia Pac Psychiatry
; 10(4): e12335, 2018 Dec.
Article
in En
| MEDLINE
| ID: mdl-30238628
ABSTRACT
INTRODUCTION:
The evidence on the association of fish or omega-3 fatty acid intake with depression is inconsistent. We conducted a systematic review and meta-analysis of prospective cohort studies to examine this association.METHODS:
Database searches in PubMed and Web of Science were conducted to identify relevant articles published up to April 2018, which were supplemented by hand-searches of reference lists of the retrieved articles. Using a random-effects model, we calculated pooled relative risks (RR) of depression in relation to consumption of fish or omega-3 fatty acids after adjusting for potential confounders.RESULTS:
A total of 10 prospective cohort studies with 6672 cases of depression among 109 764 participants were included in the meta-analysis. The pooled adjusted RR of depression for the highest vs lowest category of fish consumption was 0.89 (95% CI 0.80-0.99). The pooled adjusted RR of depression for the highest vs lowest category of omega-3 intake was 0.87 (95% CI 0.74-1.04). In the dose-response analysis, the pooled adjusted RRs for an increment of 1 serving/week of fish consumption and 500 mg/day of omega-3 fatty acid intake were 0.89 (95% CI 0.75-1.04) and 0.99 (95% CI 0.94-1.04), respectively. There was no evidence of heterogeneity.DISCUSSION:
Our findings provide quantitative evidence for a modest inverse association between fish or omega-3 fatty acid intake and risk of depression, especially in women. These findings from the observational studies need to be confirmed through large randomized clinical trials of fish consumption or omega-3 fatty acid intake and risk of depression.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fatty Acids, Omega-3
/
Prospective Studies
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Seafood
/
Depression
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Depressive Disorder
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Fishes
Type of study:
Clinical_trials
/
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limits:
Animals
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Female
/
Humans
/
Male
Language:
En
Journal:
Asia Pac Psychiatry
Year:
2018
Document type:
Article
Affiliation country:
Corea del Sur