Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.

Manjula, Ramu; Unni, Sruthi; Wright, Gareth S A; Bharath M M, Srinivas; Padmanabhan, Balasundaram

Manjula, Ramu; Unni, Sruthi; Wright, Gareth S A; Bharath M M, Srinivas; Padmanabhan, Balasundaram.

Affiliation

Manjula R; a Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
Unni S; a Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
Wright GSA; b Molecular Biophysics Group, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool , Liverpool , UK.
Bharath M M S; c Department of Neurochemistry, National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
Padmanabhan B; d Neurotoxicology Laboratory, Neurobiology Research Center, National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.

J Biomol Struct Dyn ; 37(15): 3936-3946, 2019 09.

Article in En | MEDLINE | ID: mdl-30286701

Subject(s)
Key words

ALS; NCI diversity set; SOD1; Trp oxidation; binding assay; crystal structure; modulators; phenanthridinone derivative; virtual screening

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidation-Reduction / Tryptophan / Models, Molecular / Drug Discovery / Superoxide Dismutase-1 / Amyotrophic Lateral Sclerosis Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: J Biomol Struct Dyn Year: 2019 Document type: Article Affiliation country: India Country of publication: Reino Unido

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