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Novel tacrine-pyridinium hybrid reactivators of organophosphorus-inhibited acetylcholinesterase: Synthesis, molecular docking, and in vitro reactivation study.
Kim, Jinwoo; Malpani, Yashwardhan R; Lee, Jooyun; Shin, Jin Soo; Han, Soo Bong; Jung, Young-Sik.
Affiliation
  • Kim J; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, Republic of Korea.
  • Malpani YR; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, Republic of Korea.
  • Lee J; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, Republic of Korea.
  • Shin JS; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, Republic of Korea.
  • Han SB; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, Republic of Korea; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, 217 Gajeongro, Yuseong, Daejeon 34113, Republic of Korea.
  • Jung YS; Division of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, Republic of Korea; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, 217 Gajeongro, Yuseong, Daejeon 34113, Republic of Korea. Electro
Bioorg Med Chem Lett ; 28(23-24): 3784-3786, 2018 12 15.
Article in En | MEDLINE | ID: mdl-30301674
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholinesterase / Pyridinium Compounds / Tacrine / Cholinesterase Reactivators Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholinesterase / Pyridinium Compounds / Tacrine / Cholinesterase Reactivators Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article