Fungal osteomyelitis in a patient with chronic granulomatous disease: Case report and review of the literature.
J Pak Med Assoc
; 68(9): 1387-1390, 2018 Sep.
Article
in En
| MEDLINE
| ID: mdl-30317271
ABSTRACT
Chronic granulomatous disease (CGD) is the most common of the primary immunodeficiency in children. It is caused by single gene defect resulting in dysfunctional nicotinamide adenine dineucleotide phosphate (NADPH) oxidase complex causing recurrent bacterial and fungal infections. Here we present the case of a 9 year old boy who was a known case of CGD since three years of age. He presented with recent history of fever, left sided pain in the scapular region and difficulty in breathing. Chest imaging revealed developing left upper lobe consolidation and erosion of the 3rd posterior rib. The child underwent video assisted thoracoscopic surgery (VATS) and biopsy of the lesion. Histopathology revealed fungal hyphae which were confirmed to be Aspergillus nidulans on staining. He was successfully treated with voriconazole therapy. We will also review the literature on fungal osteomyelitis in CGD patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteomyelitis
/
Aspergillosis
/
Aspergillus nidulans
/
Voriconazole
/
Granulomatous Disease, Chronic
/
Lung Diseases
Type of study:
Diagnostic_studies
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
J Pak Med Assoc
Year:
2018
Document type:
Article