A case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization.
Cardiovasc Pathol
; 37: 54-57, 2018.
Article
in En
| MEDLINE
| ID: mdl-30343188
ABSTRACT
Vaccine-associated myocarditis is an extremely rare, yet potentially lethal disease, which requires early diagnosis and prompt treatment. However, its pathogenesis remains elusive. We report the first case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization, with unique histopathologic findings, characterized by perivascular eosinophilic infiltrates with myocyte necrosis and abundant interstitial lymphocytic infiltrates with myocyte necrosis, separately. A systemic high-dose corticosteroid treatment had a dramatic beneficial effect on hemodynamic instability and resulted in complete recovery. This case highlights the value of endomyocardial biopsy in establishing a definite diagnosis and understanding the pathogenesis of vaccine-associated myocarditis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tetanus Toxoid
/
Immunization
/
Eosinophilia
/
Myocarditis
/
Myocardium
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Adolescent
/
Humans
/
Male
Language:
En
Journal:
Cardiovasc Pathol
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
/
PATOLOGIA
Year:
2018
Document type:
Article