Inflammasome inhibition prevents &#945;-synuclein pathology and dopaminergic neurodegeneration in mice.

Gordon, Richard; Albornoz, Eduardo A; Christie, Daniel C; Langley, Monica R; Kumar, Vinod; Mantovani, Susanna; Robertson, Avril A B; Butler, Mark S; Rowe, Dominic B; O'Neill, Luke A; Kanthasamy, Anumantha G; Schroder, Kate; Cooper, Matthew A; Woodruff, Trent M

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.

Gordon, Richard; Albornoz, Eduardo A; Christie, Daniel C; Langley, Monica R; Kumar, Vinod; Mantovani, Susanna; Robertson, Avril A B; Butler, Mark S; Rowe, Dominic B; O'Neill, Luke A; Kanthasamy, Anumantha G; Schroder, Kate; Cooper, Matthew A; Woodruff, Trent M.

Affiliation

Gordon R; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, Queensland 4072, Australia.
Albornoz EA; UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Herston, Queensland 4092, Australia.
Christie DC; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, Queensland 4072, Australia.
Langley MR; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia.
Kumar V; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, Queensland 4072, Australia.
Mantovani S; Parkinson Disorders Research Program, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
Robertson AAB; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, Queensland 4072, Australia.
Butler MS; UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Herston, Queensland 4092, Australia.
Rowe DB; Department of Neurology, Royal Brisbane and Women's Hospital, Herston, Queensland 4006, Australia.
O'Neill LA; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia.
Kanthasamy AG; School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia.
Schroder K; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia.
Cooper MA; Department of Neurology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Woodruff TM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Dublin 2, Ireland.

Sci Transl Med ; 10(465)2018 10 31.

Article in En | MEDLINE | ID: mdl-30381407

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha-Synuclein / Inflammasomes / Dopaminergic Neurons / Nerve Degeneration Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: Australia Country of publication: Estados Unidos

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