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Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia.
Bai, Haihua; Guo, Xiaosen; Narisu, Narisu; Lan, Tianming; Wu, Qizhu; Xing, Yanping; Zhang, Yong; Bond, Stephen R; Pei, Zhili; Zhang, Yanru; Zhang, Dandan; Jirimutu, Jirimutu; Zhang, Dong; Yang, Xukui; Morigenbatu, Morigenbatu; Zhang, Li; Ding, Bingyi; Guan, Baozhu; Cao, Junwei; Lu, Haorong; Liu, Yiyi; Li, Wangsheng; Dang, Ningxin; Jiang, Mingyang; Wang, Shenyuan; Xu, Huixin; Wang, Dingzhu; Liu, Chunxia; Luo, Xin; Gao, Ying; Li, Xueqiong; Wu, Zongze; Yang, Liqing; Meng, Fanhua; Ning, Xiaolian; Hashenqimuge, Hashenqimuge; Wu, Kaifeng; Wang, Bo; Suyalatu, Suyalatu; Liu, Yingchun; Ye, Chen; Wu, Huiguang; Leppälä, Kalle; Li, Lu; Fang, Lin; Chen, Yujie; Xu, Wenhao; Li, Tao; Liu, Xin; Xu, Xun.
Affiliation
  • Bai H; School of Life Science, Inner Mongolia University for the Nationalities, Tongliao, China.
  • Guo X; Inner Mongolia Engineering Research Center of Personalized Medicine, Tongliao, China.
  • Narisu N; BGI-Shenzhen, Shenzhen, China.
  • Lan T; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Wu Q; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Xing Y; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Zhang Y; BGI-Shenzhen, Shenzhen, China.
  • Bond SR; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Pei Z; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Zhang Y; Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China.
  • Zhang D; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Jirimutu J; BGI-Shenzhen, Shenzhen, China.
  • Zhang D; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Yang X; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Morigenbatu M; College of Computer Science and Technology, Inner Mongolia University for the Nationalities, Tongliao, China.
  • Zhang L; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Ding B; BGI-Shenzhen, Shenzhen, China.
  • Guan B; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Cao J; College of Mathematics, Inner Mongolia University for the Nationalities, Tongliao, China.
  • Lu H; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Liu Y; BGI Genomics, BGI-Shenzhen, Shenzhen, China.
  • Li W; College of Mongolian Studies, Inner Mongolia University for the Nationalities, Tongliao, China.
  • Dang N; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Jiang M; BGI-Shenzhen, Shenzhen, China.
  • Wang S; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Xu H; Inner Mongolia International Mongolian Hospital, Hohhot, China.
  • Wang D; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Liu C; BGI-Shenzhen, Shenzhen, China.
  • Luo X; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Gao Y; Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, China.
  • Li X; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Wu Z; BGI-Shenzhen, Shenzhen, China.
  • Yang L; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Meng F; BGI-Shenzhen, Shenzhen, China.
  • Ning X; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Hashenqimuge H; College of Computer Science and Technology, Inner Mongolia University for the Nationalities, Tongliao, China.
  • Wu K; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Wang B; BGI-Shenzhen, Shenzhen, China.
  • Suyalatu S; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Liu Y; College of Mongolian Studies, Inner Mongolia University for the Nationalities, Tongliao, China.
  • Ye C; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Wu H; BGI-Shenzhen, Shenzhen, China.
  • Leppälä K; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Li L; School of Life Science, Inner Mongolia University for the Nationalities, Tongliao, China.
  • Fang L; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Chen Y; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Xu W; BGI Genomics, BGI-Shenzhen, Shenzhen, China.
  • Li T; Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, China.
  • Liu X; College of Life Science, Inner Mongolia Agricultural University, Hohhot, China.
  • Xu X; BGI-Shenzhen, Shenzhen, China.
Nat Genet ; 50(12): 1696-1704, 2018 12.
Article in En | MEDLINE | ID: mdl-30397334
ABSTRACT
The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asian People / Genetics, Population Type of study: Prognostic_studies Limits: Female / Humans / Male Country/Region as subject: Asia / Europa Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2018 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asian People / Genetics, Population Type of study: Prognostic_studies Limits: Female / Humans / Male Country/Region as subject: Asia / Europa Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2018 Document type: Article Affiliation country: China