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Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy.
Classen, G; Classen, C; Bernasconi, C; Brandt, C; Gold, R; Chan, A; Hoepner, R.
Affiliation
  • Classen G; Department of Paediatric Neurology, Evangelisches Klinikum Bethel, Bielefeld, Germany.
  • Classen C; Department of Computer Science, TU Dortmund University, Dortmund, Germany.
  • Bernasconi C; Clinical Trial Unit, Neurocentre Bern, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Brandt C; Department of General Epileptology, Bethel Epilepsy Centre, Bielefeld, Germany.
  • Gold R; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
  • Chan A; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
  • Hoepner R; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
J Neurovirol ; 25(1): 133-136, 2019 02.
Article in En | MEDLINE | ID: mdl-30414049
ABSTRACT
Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88%) and specificity (82%) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukoencephalopathy, Progressive Multifocal / JC Virus / Multiple Sclerosis, Relapsing-Remitting / Electroencephalography / Natalizumab / Immunologic Factors Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Neurovirol Journal subject: NEUROLOGIA / VIROLOGIA Year: 2019 Document type: Article Affiliation country: Alemania
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukoencephalopathy, Progressive Multifocal / JC Virus / Multiple Sclerosis, Relapsing-Remitting / Electroencephalography / Natalizumab / Immunologic Factors Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Neurovirol Journal subject: NEUROLOGIA / VIROLOGIA Year: 2019 Document type: Article Affiliation country: Alemania