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Aminoethane Sulfonic Acid Magnesium Salt Inhibits Ca2+ Entry Through NMDA Receptor Ion Channel In Vitro.
Turovsky, E A; Blinova, E V; Semeleva, E V; Zinchenko, V P; Astashev, M E; Blinov, D S; Skachilova, S Ya; Geras'kina, M M; Lebedev, A B; Gromova, I A.
Affiliation
  • Turovsky EA; Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Russia.
  • Blinova EV; N. P. Ogarev National Research Mordovian State University, Saransk, Russia. bev-saransk@yandex.ru.
  • Semeleva EV; N. P. Ogarev National Research Mordovian State University, Saransk, Russia.
  • Zinchenko VP; Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Russia.
  • Astashev ME; Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Russia.
  • Blinov DS; Russian Research Center for Safety of Bioactive Substances, Staraya Kupavna, Russia.
  • Skachilova SY; Russian Research Center for Safety of Bioactive Substances, Staraya Kupavna, Russia.
  • Geras'kina MM; N. P. Ogarev National Research Mordovian State University, Saransk, Russia.
  • Lebedev AB; Russian Research Center for Safety of Bioactive Substances, Staraya Kupavna, Russia.
  • Gromova IA; N. P. Ogarev National Research Mordovian State University, Saransk, Russia.
Bull Exp Biol Med ; 166(1): 39-42, 2018 Nov.
Article in En | MEDLINE | ID: mdl-30417298
ABSTRACT
The effect of a cerebroprotective agent magnesium bis-aminoethanesulfonate (laboratory code FS-LKhT-317) on intracellular calcium concentration was studied by the fluorescent imaging technique on neuroglial cell culture from Spraque-Dawley rat hippocampus. The substance produced a pronounced inhibitory effect and suppressed NMDA receptor activity in concentrations of ≥50 µM. The observed effects were reversible or partially reversible and were detected by a decrease in Ca2+ signal amplitude in neurons in response to NMDA applications in a Mg2+-free medium and by inhibition of Ca2+ pulses in magnesium-free medium (elimination of magnesium block).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium / Receptors, N-Methyl-D-Aspartate / Alkanesulfonates / Magnesium Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2018 Document type: Article Affiliation country: Rusia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium / Receptors, N-Methyl-D-Aspartate / Alkanesulfonates / Magnesium Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2018 Document type: Article Affiliation country: Rusia