Tailoring of Proteostasis Networks with Heat Shock Factors.
Cold Spring Harb Perspect Biol
; 11(4)2019 04 01.
Article
in En
| MEDLINE
| ID: mdl-30420555
ABSTRACT
Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival. The mechanisms that are used to tailor HSF-driven proteostasis networks are not yet completely understood, but they likely comprise from distinct combinations of both genetic and proteomic determinants. In this review, we highlight the versatile HSF-mediated cellular functions that extend from cellular stress responses to various physiological and pathological processes, and we underline the key advancements that have been achieved in the field of HSF research during the last decade.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heat Shock Transcription Factors
/
Proteostasis
Limits:
Animals
/
Humans
Language:
En
Journal:
Cold Spring Harb Perspect Biol
Journal subject:
BIOLOGIA
Year:
2019
Document type:
Article
Affiliation country:
Finlandia