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Gestational stress induced differential expression of HDAC2 in male rat offspring hippocampus during development.
Liao, Libin; Wang, Xueqin; Yao, Xueping; Zhang, Bin; Zhou, Lihong; Huang, Jufang.
Affiliation
  • Liao L; Department of Anatomy and Neurobiology, Central South University School of Basic Medical Sciences, Changsha, Hunan, PR China; Department of Histology and Embryology, Basic Medical College of Xinjiang Medical University, Ürümqi, Xinjiang, PR China.
  • Wang X; Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
  • Yao X; Department of Mechanism Lab Centre, Basic Medical College of Xinjiang Medical University, Ürümqi, Xinjiang, PR China.
  • Zhang B; Department of Anatomy and Neurobiology, Central South University School of Basic Medical Sciences, Changsha, Hunan, PR China.
  • Zhou L; Department of Human Anatomy, School of Medicine, Hunan Normal University, Changsha, Hunan, PR China. Electronic address: angel8858zlh@163.com.
  • Huang J; Department of Anatomy and Neurobiology, Central South University School of Basic Medical Sciences, Changsha, Hunan, PR China. Electronic address: huangjufang@csu.edu.cn.
Neurosci Res ; 147: 9-16, 2019 Oct.
Article in En | MEDLINE | ID: mdl-30452948
Accumulating evidence from preclinical and clinical studies indicates prenatal exposure to stress or excess glucocorticoids can affect offspring brain. HDAC2 is an important target of glucocorticoid. Here we detected HDAC2 expression in male offspring hippocampus from gestational restraint stressed rat during development and the relationship between HDAC2 expression and behaviors and neurogenesis in male offspring. Pregnant rats received restrained stress during the last week of pregnancy. Expressions of HDAC2 in offspring hippocampus were detected on postnatal 0 day (P0) and 60 days (P60). Neurogenesis was evaluated by Doublecortin (DCX) staining on P60. Anxiety-like behavior and cognition were detected in open field, elevated plus maze, novel object recognition test, and Barnes maze. We found that HDAC2 expression in the hippocampus of male prenatally stressed offspring (MPSO) was similar to the male control offspring on P0, but significantly lower on P60. Corresponding to the decreased expression of HDAC2 in MPSO hippocampus at P60, neurogenesis in the dentate gyrus of MPSO was significantly lower than the control male offspring. And MPSO also showed greater anxiety and poorer learning and memories abilities than control male offspring. These showed that HDAC2 could partly explain the effects of gestational stress on male offspring behaviors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications / Prenatal Exposure Delayed Effects / Histone Deacetylase 2 / Hippocampus Limits: Animals / Pregnancy Language: En Journal: Neurosci Res Journal subject: NEUROLOGIA Year: 2019 Document type: Article Country of publication: Irlanda

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications / Prenatal Exposure Delayed Effects / Histone Deacetylase 2 / Hippocampus Limits: Animals / Pregnancy Language: En Journal: Neurosci Res Journal subject: NEUROLOGIA Year: 2019 Document type: Article Country of publication: Irlanda