Zinc transporter 8 autoantibodies (ZnT8-ab) are associated with higher prevalence of multiple diabetes-related autoantibodies in adults with type 1 diabetes.
Diabetes Res Clin Pract
; 146: 313-320, 2018 Dec.
Article
in En
| MEDLINE
| ID: mdl-30465779
ABSTRACT
AIM:
The study aimed to assess the prevalence of zinc transporter 8 autoantibodies (ZnT8-ab), other diabetes-related autoantibodies and clinical manifestation of type 1 diabetes in adults, depending on age of the onset of disease.METHODS:
119 patients with type 1 diabetes, 66 at age <35â¯years (T1DMâ¯<â¯35) and 53 T1DM at age ≥35â¯years (T1DMâ¯≥â¯35). We assessed clinical features, GAD-ab, IA2-ab, ICA, ZnT8-ab and thyroid peroxidase antibodies (ATPO).RESULTS:
In T1DMâ¯<â¯35 lower initial serum C-peptide concentration was observed and diabetes ketoacidosis (DKA) was more common. ATPO positivity was more prevalent in T1DMâ¯≥â¯35 (35.8 vs 21.2%, pâ¯=â¯0.04). The prevalence of GAD-ab, IA2-ab and ZnT8-ab was similar in both groups, the titres of IA2-ab and ICA were higher in T1DMâ¯<â¯35 but titre of ZnT8-ab was higher in T1DMâ¯≥â¯35. The majority of T1DMâ¯<â¯35 patients were positive for three autoantibodies (40.9%), while T1DMâ¯≥â¯35 subjects most often presented with only one (30.2%) antibody, most commonly GAD-ab (81.2%). 45% T1DMâ¯<â¯35 and 34% T1DMâ¯≥â¯35 subjects were positive for ZnT8-ab. ZnT8-ab positive patients had higher titre and more frequent occurrence of multiple diabetes-related autoantibodies than ZnT8-ab negative patients.CONCLUSIONS:
Adults with T1DMâ¯<â¯35 and T1DMâ¯≥â¯35 differ in the severity of autoimmune response at diagnosis. ZnT8-ab positivity is related to higher titre and more frequent occurrence of multiple diabetes-related autoantibodies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoantibodies
/
Diabetes Mellitus, Type 1
/
Zinc Transporter 8
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Diabetes Res Clin Pract
Journal subject:
ENDOCRINOLOGIA
Year:
2018
Document type:
Article