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Geospallins A⁻C: New Thiodiketopiperazines with Inhibitory Activity against Angiotensin-Converting Enzyme from a Deep-Sea-Derived Fungus Geosmithia pallida FS140.
Sun, Zhang-Hua; Gu, Jiangyong; Ye, Wei; Wen, Liang-Xi; Lin, Qi-Bin; Li, Sai-Ni; Chen, Yu-Chan; Li, Hao-Hua; Zhang, Wei-Min.
Affiliation
  • Sun ZH; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China. sysuszh@126.com.
  • Gu J; Guangdong Provincial Key Laboratory of New Drug, Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. sysuszh@126.com.
  • Ye W; The Second Institute of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. gujy@gzucm.edu.cn.
  • Wen LX; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China. yewei@gdim.cn.
  • Lin QB; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. wen_en_liangxi@163.com.
  • Li SN; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. 15622154060@163.com.
  • Chen YC; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China. lisn@gdim.cn.
  • Li HH; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China. yuchan2006@126.com.
  • Zhang WM; State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China. hhli100@126.com.
Mar Drugs ; 16(12)2018 Nov 23.
Article in En | MEDLINE | ID: mdl-30477129
Three new thiodiketopiperazines, geospallins A⁻C (1⁻3), together with nine known analogues (4⁻12), were isolated from the culture of the deep-sea sediment-derived fungus Geosmithia pallida FS140. Among them, geospallins A and B (1 and 2) represent rare examples of thiodiketopiperazines featuring an S-methyl group at C-10 and a tertiary hydroxyl group at C-11. Their structures were determined by high-resolution electrospray mass spectrometry (HRESIMS), spectroscopic analyses, and electronic circular dichroism (ECD) calculations. Their angiotensin-converting enzyme (ACE) inhibitory activity was reported, and geospallins A⁻C (1⁻3) showed inhibitory activity with IC50 values of 29⁻35 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Angiotensin-Converting Enzyme Inhibitors / Peptidyl-Dipeptidase A / Aquatic Organisms / Hypocreales Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: Suiza
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Angiotensin-Converting Enzyme Inhibitors / Peptidyl-Dipeptidase A / Aquatic Organisms / Hypocreales Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: Suiza