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Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment.
van Geffen, Ellen Wilhelmina; van Caam, Arjan Petrus Maria; Vitters, Elly Louise; van Beuningen, Henk Maria; van de Loo, Fons Adrianus; van Lent, Peter Leonardus Everardus Maria; Koenders, Marije Ingrid; van der Kraan, Peter Mario.
Affiliation
  • van Geffen EW; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Caam APM; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Vitters EL; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Beuningen HM; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • van de Loo FA; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Lent PLEM; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Koenders MI; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • van der Kraan PM; Department of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
Tissue Eng Part A ; 25(15-16): 1155-1166, 2019 08.
Article in En | MEDLINE | ID: mdl-30526407
ABSTRACT
IMPACT STATEMENT Catabolic factors present in a damaged joint inhibit chondrogenic differentiation of mesenchymal stem cells, thereby reducing the chance for successful cartilage formation. By improving stem cell-based cartilage repair with interleukin-37 (IL37), we might be able to inhibit the worsening progression of focal cartilage defects and prevent further development of joint diseases such as osteoarthritis. This will avoid chronic pain and impaired joint mobility for patients and reduce costs for society.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Interleukin-1 / Cytoprotection / Chondrogenesis / Mesenchymal Stem Cells / Cellular Microenvironment / Inflammation Limits: Humans Language: En Journal: Tissue Eng Part A Journal subject: BIOTECNOLOGIA / HISTOLOGIA Year: 2019 Document type: Article Affiliation country: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Interleukin-1 / Cytoprotection / Chondrogenesis / Mesenchymal Stem Cells / Cellular Microenvironment / Inflammation Limits: Humans Language: En Journal: Tissue Eng Part A Journal subject: BIOTECNOLOGIA / HISTOLOGIA Year: 2019 Document type: Article Affiliation country: Países Bajos