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DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
Rojas, Camilo; Barnaeva, Elena; Thomas, Ajit G; Hu, Xin; Southall, Noel; Marugan, Juan; Chaudhuri, Amrita Datta; Yoo, Seung-Wan; Hin, Niyada; Stepanek, Ondrej; Wu, Ying; Zimmermann, Sarah C; Gadiano, Alexandra G; Tsukamoto, Takashi; Rais, Rana; Haughey, Norman; Ferrer, Marc; Slusher, Barbara S.
Affiliation
  • Rojas C; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Barnaeva E; Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Thomas AG; National Center for Advancing Translational Sciences (NCATS), National Institute of Health, Bethesda, MD, 20892-3370, USA.
  • Hu X; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Southall N; National Center for Advancing Translational Sciences (NCATS), National Institute of Health, Bethesda, MD, 20892-3370, USA.
  • Marugan J; National Center for Advancing Translational Sciences (NCATS), National Institute of Health, Bethesda, MD, 20892-3370, USA.
  • Chaudhuri AD; National Center for Advancing Translational Sciences (NCATS), National Institute of Health, Bethesda, MD, 20892-3370, USA.
  • Yoo SW; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Hin N; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Stepanek O; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Wu Y; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Zimmermann SC; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Gadiano AG; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Tsukamoto T; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Rais R; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Haughey N; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Ferrer M; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
  • Slusher BS; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore, Maryland, 21205, USA.
Sci Rep ; 8(1): 17715, 2018 12 07.
Article in En | MEDLINE | ID: mdl-30531925
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingomyelin Phosphodiesterase / Brain / Astrocytes / Encephalitis / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingomyelin Phosphodiesterase / Brain / Astrocytes / Encephalitis / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: Estados Unidos