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Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
Shrine, Nick; Portelli, Michael A; John, Catherine; Soler Artigas, María; Bennett, Neil; Hall, Robert; Lewis, Jon; Henry, Amanda P; Billington, Charlotte K; Ahmad, Azaz; Packer, Richard J; Shaw, Dominick; Pogson, Zara E K; Fogarty, Andrew; McKeever, Tricia M; Singapuri, Amisha; Heaney, Liam G; Mansur, Adel H; Chaudhuri, Rekha; Thomson, Neil C; Holloway, John W; Lockett, Gabrielle A; Howarth, Peter H; Djukanovic, Ratko; Hankinson, Jenny; Niven, Robert; Simpson, Angela; Chung, Kian Fan; Sterk, Peter J; Blakey, John D; Adcock, Ian M; Hu, Sile; Guo, Yike; Obeidat, Maen; Sin, Don D; van den Berge, Maarten; Nickle, David C; Bossé, Yohan; Tobin, Martin D; Hall, Ian P; Brightling, Christopher E; Wain, Louise V; Sayers, Ian.
Affiliation
  • Shrine N; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Portelli MA; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • John C; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Soler Artigas M; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Bennett N; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Hall R; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • Lewis J; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • Henry AP; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • Billington CK; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • Ahmad A; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • Packer RJ; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Shaw D; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • Pogson ZEK; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
  • Fogarty A; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
  • McKeever TM; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
  • Singapuri A; Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK; Glenfield Hospital, Leicester, UK.
  • Heaney LG; Centre for Infection and Immunity, Queen's University of Belfast, Belfast, UK.
  • Mansur AH; Respiratory Medicine, Birmingham Heartlands Hospital and University of Birmingham, Birmingham, UK.
  • Chaudhuri R; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
  • Thomson NC; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
  • Holloway JW; Human Development and Health, Clinical and Experimental Sciences, Faculty of Medicine and National Institute of Health Biomedical Research Centre, Southampton, University of Southampton, Southampton, UK.
  • Lockett GA; Human Development and Health, Clinical and Experimental Sciences, Faculty of Medicine and National Institute of Health Biomedical Research Centre, Southampton, University of Southampton, Southampton, UK.
  • Howarth PH; Human Development and Health, Clinical and Experimental Sciences, Faculty of Medicine and National Institute of Health Biomedical Research Centre, Southampton, University of Southampton, Southampton, UK.
  • Djukanovic R; Human Development and Health, Clinical and Experimental Sciences, Faculty of Medicine and National Institute of Health Biomedical Research Centre, Southampton, University of Southampton, Southampton, UK.
  • Hankinson J; Division of Infection Immunity and Respiratory Medicine, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, UK.
  • Niven R; Division of Infection Immunity and Respiratory Medicine, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, UK.
  • Simpson A; Division of Infection Immunity and Respiratory Medicine, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, UK.
  • Chung KF; The National Heart and Lung Institute, Imperial College, London, UK.
  • Sterk PJ; Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
  • Blakey JD; Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia.
  • Adcock IM; The National Heart and Lung Institute, Imperial College, London, UK.
  • Hu S; Data Science Institute, Imperial College, London, UK.
  • Guo Y; Data Science Institute, Imperial College, London, UK.
  • Obeidat M; The University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital Vancouver, Vancouver, BC, Canada.
  • Sin DD; The University of British Columbia Center for Heart Lung Innovation, St Paul's Hospital Vancouver, Vancouver, BC, Canada; Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • van den Berge M; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen Research Institute for Asthma and COPD Research Institute, Groningen, Netherlands.
  • Nickle DC; Merck & Co Inc, Rahway, NJ, USA.
  • Bossé Y; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, QC, Canada.
  • Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Hall IP; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
  • Brightling CE; Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, University of Leicester, Leicester, UK; Glenfield Hospital, Leicester, UK.
  • Wain LV; Department of Health Sciences, University of Leicester, Leicester, UK; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Sayers I; Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address: ian.sayers@nottingham.ac.uk.
Lancet Respir Med ; 7(1): 20-34, 2019 Jan.
Article in En | MEDLINE | ID: mdl-30552067
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Proteins / Genetic Predisposition to Disease / GATA3 Transcription Factor / Mucin 5AC Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Respir Med Year: 2019 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Proteins / Genetic Predisposition to Disease / GATA3 Transcription Factor / Mucin 5AC Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Respir Med Year: 2019 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido