KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons.

You, Zhenyuan; Zhang, Zheng; Blagg, Brian S J; Dobrowsky, Rick T

You, Zhenyuan; Zhang, Zheng; Blagg, Brian S J; Dobrowsky, Rick T.

Affiliation

You Z; Department of Pharmacology and Toxicology, University of Kansas, 5064 Malott Hall, 1251 Wescoe Hall Dr., Lawrence, KS 66045, USA.
Zhang Z; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA.
Blagg BSJ; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, USA. Electronic address: bblagg@nd.edu.
Dobrowsky RT; Department of Pharmacology and Toxicology, University of Kansas, 5064 Malott Hall, 1251 Wescoe Hall Dr., Lawrence, KS 66045, USA. Electronic address: dobrowsky@ku.edu.

Exp Neurol ; 313: 88-97, 2019 03.

Article in En | MEDLINE | ID: mdl-30557564

Subject(s)
Key words

C-terminal Hsp90 inhibitors; Diabetic peripheral neuropathy; Molecular chaperones; Neuroprotection; Sensory neurons

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenethylamines / Sensory Receptor Cells / Superoxide Dismutase / Superoxides / Energy Metabolism / Glycosides / Mitochondria Limits: Animals Language: En Journal: Exp Neurol Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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