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Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies.
Kapron, Barbara; Luszczki, Jarogniew J; Plazinska, Anita; Siwek, Agata; Karcz, Tadeusz; Grybos, Anna; Nowak, Gabriel; Makuch-Kocka, Anna; Walczak, Katarzyna; Langner, Ewa; Szalast, Karolina; Marciniak, Sebastian; Paczkowska, Magdalena; Cielecka-Piontek, Judyta; Ciesla, Lukasz M; Plech, Tomasz.
Affiliation
  • Kapron B; Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland.
  • Luszczki JJ; Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.
  • Plazinska A; Department of Biopharmacy, Medical University of Lublin, Lublin, Poland.
  • Siwek A; Department of Pharmacobiology, Jagiellonian University Medical College, Cracow, Poland.
  • Karcz T; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Cracow, Poland.
  • Grybos A; Department of Pharmacobiology, Jagiellonian University Medical College, Cracow, Poland.
  • Nowak G; Department of Pharmacobiology, Jagiellonian University Medical College, Cracow, Poland.
  • Makuch-Kocka A; Department of Pharmacology, Medical University of Lublin, Lublin, Poland.
  • Walczak K; Department of Pharmacology, Medical University of Lublin, Lublin, Poland.
  • Langner E; Department of Pharmacology, Medical University of Lublin, Lublin, Poland.
  • Szalast K; Department of Pharmacology, Medical University of Lublin, Lublin, Poland.
  • Marciniak S; Department of Pharmacology, Medical University of Lublin, Lublin, Poland.
  • Paczkowska M; Department of Pharmacognosy, Poznan University of Medical Sciences, Poznan, Poland.
  • Cielecka-Piontek J; Department of Pharmacognosy, Poznan University of Medical Sciences, Poznan, Poland.
  • Ciesla LM; Department of Biological Sciences, The University of Alabama, Tuscaloosa, USA.
  • Plech T; Department of Pharmacology, Medical University of Lublin, Lublin, Poland. Electronic address: tomasz.plech@umlub.pl.
Eur J Pharm Sci ; 129: 42-57, 2019 Mar 01.
Article in En | MEDLINE | ID: mdl-30594731
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Voltage-Gated Sodium Channels / Anticonvulsants Limits: Animals / Humans Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2019 Document type: Article Affiliation country: Polonia Country of publication: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Voltage-Gated Sodium Channels / Anticonvulsants Limits: Animals / Humans Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2019 Document type: Article Affiliation country: Polonia Country of publication: Países Bajos