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Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity.
Massalha, Wessal; Markovits, Mark; Pichinuk, Edward; Feinstein-Rotkopf, Yael; Tarshish, Mark; Mishra, Kumudesh; Llado, Victoria; Weil, Miguel; Escriba, Pablo V; Kakhlon, Or.
Affiliation
  • Massalha W; Department of Neurology, Hadassah-Hebrew University Medical Center, Ein Kerem, 91120 Jerusalem, Israel.
  • Markovits M; Laboratory for Neurodegenerative Diseases and Personalized Medicine, Department of Cell Research and Immunology, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel.
  • Pichinuk E; Laboratory for Neurodegenerative Diseases and Personalized Medicine, Department of Cell Research and Immunology, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel.
  • Feinstein-Rotkopf Y; Light Microscopy Lab, Core Research Facility, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120 Jerusalem, Israel.
  • Tarshish M; Light Microscopy Lab, Core Research Facility, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, 91120 Jerusalem, Israel.
  • Mishra K; Department of Neurology, Hadassah-Hebrew University Medical Center, Ein Kerem, 91120 Jerusalem, Israel.
  • Llado V; Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Ctra. de Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain.
  • Weil M; Laboratory for Neurodegenerative Diseases and Personalized Medicine, Department of Cell Research and Immunology, The George S. Wise Faculty for Life Sciences, Sagol School of Neurosciences, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel.
  • Escriba PV; Laboratory of Molecular Cell Biomedicine, Department of Biology, University of the Balearic Islands, Ctra. de Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain.
  • Kakhlon O; Department of Neurology, Hadassah-Hebrew University Medical Center, Ein Kerem, 91120 Jerusalem, Israel ork@hadassah.org.il.
Biosci Rep ; 39(1)2019 01 31.
Article in En | MEDLINE | ID: mdl-30602451
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleic Acids / Energy Metabolism / Lung Neoplasms Type of study: Etiology_studies Limits: Humans Language: En Journal: Biosci Rep Year: 2019 Document type: Article Affiliation country: Israel Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleic Acids / Energy Metabolism / Lung Neoplasms Type of study: Etiology_studies Limits: Humans Language: En Journal: Biosci Rep Year: 2019 Document type: Article Affiliation country: Israel Country of publication: Reino Unido