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Neonatal Lethality and Inflammatory Phenotype of the New Transgenic Mice with Overexpression of Human Interleukin-6 in Myeloid Cells.
Zvartsev, R V; Korshunova, D S; Gorshkova, E A; Nosenko, M A; Korneev, K V; Maksimenko, O G; Korobko, I V; Kuprash, D V; Drutskaya, M S; Nedospasov, S A; Deikin, A V.
Affiliation
  • Zvartsev RV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
  • Korshunova DS; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • Gorshkova EA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
  • Nosenko MA; Department of Immunology, Biological Faculty, Moscow State University, Moscow, 119991, Russia.
  • Korneev KV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
  • Maksimenko OG; Department of Immunology, Biological Faculty, Moscow State University, Moscow, 119991, Russia.
  • Korobko IV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
  • Kuprash DV; Department of Immunology, Biological Faculty, Moscow State University, Moscow, 119991, Russia.
  • Drutskaya MS; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • Nedospasov SA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
  • Deikin AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Dokl Biochem Biophys ; 483(1): 344-347, 2018 Nov.
Article in En | MEDLINE | ID: mdl-30607736
ABSTRACT
To model human interleukin-6 (hIL-6) associated diseases, unique mice with transgenic overexpression of human IL-6 and reporter fluorescent protein EGFP in cells of macrophage-monocyte lineage were generated using loxP-Cre system. High level of hIL-6 production by macrophages and monocytes, as confirmed in vitro in primary culture of bone marrow-derived macrophages, in vivo resulted in early postnatal death in vivo, presumably, due to the effect of overexpression of hIL-6 on hematopoiesis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Interleukin-6 / Hematopoiesis / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Dokl Biochem Biophys Journal subject: BIOFISICA / BIOQUIMICA Year: 2018 Document type: Article Affiliation country: Rusia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Interleukin-6 / Hematopoiesis / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Dokl Biochem Biophys Journal subject: BIOFISICA / BIOQUIMICA Year: 2018 Document type: Article Affiliation country: Rusia