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First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.
Pitchford, Lisa M; Rathmacher, John A; Fuller, John C; Daniels, J Scott; Morrison, Ryan D; Akers, Wendall S; Abumrad, Naji N; Amarnath, Venkataraman; Currey, Patricia M; Roberts, L Jackson; Oates, John A; Boutaud, Olivier.
Affiliation
  • Pitchford LM; Metabolic Technologies, Inc., Ames, IA, 50010, USA. pitchford@mti-hmb.com.
  • Rathmacher JA; Metabolic Technologies, Inc., Ames, IA, 50010, USA.
  • Fuller JC; Department of Animal Science, Iowa State University, Ames, IA, 50010, USA.
  • Daniels JS; Metabolic Technologies, Inc., Ames, IA, 50010, USA.
  • Morrison RD; Sano Informed Prescribing Inc., Franklin, TN, 37067, USA.
  • Akers WS; Sano Informed Prescribing Inc., Franklin, TN, 37067, USA.
  • Abumrad NN; Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, TN, 37204, USA.
  • Amarnath V; Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
  • Currey PM; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Roberts LJ; Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Oates JA; Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Boutaud O; Department of Pharmacology, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
BMC Pharmacol Toxicol ; 20(1): 1, 2019 Jan 05.
Article in En | MEDLINE | ID: mdl-30611293
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylamines / Neuroprotective Agents / Dietary Supplements / Acetates Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: BMC Pharmacol Toxicol Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylamines / Neuroprotective Agents / Dietary Supplements / Acetates Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: BMC Pharmacol Toxicol Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido