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3,5-Disubstituted-indole-7-carboxamides as IKKß Inhibitors: Optimization of Oral Activity via the C3 Substituent.
Kerns, Jeffrey K; Busch-Petersen, Jakob; Fu, Wei; Boehm, Jeffrey C; Nie, Hong; Muratore, Michael; Bullion, Ann; Lin, Guoliang; Li, Huijie; Davis, Roderick; Lin, Xichen; Lakdawala, Ami S; Cousins, Rick; Field, Rita; Payne, Jeremy; Miller, David D; Bamborough, Paul; Christopher, John A; Baldwin, Ian; Osborn, Ruth R; Yonchuk, John; Webb, Edward; Rumsey, William L.
Affiliation
  • Kerns JK; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Busch-Petersen J; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Fu W; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Boehm JC; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Nie H; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Muratore M; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Bullion A; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Lin G; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Li H; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Davis R; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Lin X; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Lakdawala AS; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Cousins R; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Field R; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Payne J; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Miller DD; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Bamborough P; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Christopher JA; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Baldwin I; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Osborn RR; Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
  • Yonchuk J; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Webb E; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
  • Rumsey WL; GlaxoSmithKline Inc., 709 Swedeland Road, King of Prussia Pennsylvania 19406, United States.
ACS Med Chem Lett ; 9(12): 1164-1169, 2018 Dec 13.
Article in En | MEDLINE | ID: mdl-30613320

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: ACS Med Chem Lett Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: ACS Med Chem Lett Year: 2018 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos