7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease.
Neuroimage Clin
; 21: 101665, 2019.
Article
in En
| MEDLINE
| ID: mdl-30642758
ABSTRACT
Using 7T T2â-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes in Alzheimer patients versus controls. While controls showed a hypointense line of Baillarger in the majority of the cases, appearance of cortical lamination varied to a greater extent in the Alzheimer patients. Severely distorted cortical lamination was also observed in advanced stage Alzheimer patients and presented itself as a broad hypointense inhomogeneous band, covering a large part of the cortical width. Histology indicated that the changes in the appearance of visible cortical lamination were not only associated with myelin changes, but also with diffuse cortical iron alterations and depositions. Therefore, imaging cortical lamination alterations in Alzheimer patients using T2*-weighted MRI might provide new information on involved neuroanatomical structures in an advanced neurodegenerative stage.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Temporal Lobe
/
Cerebral Cortex
/
Alzheimer Disease
/
Myelin Sheath
Type of study:
Diagnostic_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neuroimage Clin
Year:
2019
Document type:
Article