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Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination.
Huang, Hui; Meegalla, Sanath K; Lanter, James C; Winters, Michael P; Zhao, Shuyuan; Littrell, James; Qi, Jenson; Rady, Brian; Lee, Paul S; Liu, Jianying; Martin, Tonya; Lam, Wing W; Xu, Fran; Lim, Heng Keang; Wilde, Thomas; Silva, Jose; Otieno, Monicah; Pocai, Alessandro; Player, Mark R.
Affiliation
  • Huang H; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Meegalla SK; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Lanter JC; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Winters MP; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Zhao S; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Littrell J; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Qi J; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Rady B; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Lee PS; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Liu J; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Martin T; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Lam WW; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Xu F; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Lim HK; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Wilde T; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Silva J; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Otieno M; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Pocai A; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
  • Player MR; Departments of Medicinal Chemistry, Cardiovascular & Metabolism in Vitro Biology, Cardiovascular & Metabolism in Vivo Pharmacology, andPreclinical Drug Safety, Janssen Research & Development, Welsh and McKean Roads,Spring House, Pennsylvania 19477-0776, United States.
ACS Med Chem Lett ; 10(1): 16-21, 2019 Jan 10.
Article in En | MEDLINE | ID: mdl-30655940
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos