Developing a drug delivery carrier from natural polysaccharide exudate gum by graft-copolymerization reaction using high energy radiations.

ABSTRACT

Keeping in view the importance of natural polysaccharide exudate gum in developing drug formulations. Herein this work, for making sterile drug carrier, the chemical modification of the gum polysaccharides has been carried out by graft copolymerization reaction by high energy radiation in the presence of biocompatible hydrophilic monomer N-vinyl imidazole and graphene oxide (GO). Cryo-SEM showed the porous nature of the polymer matrix. The crosslinking density of the material was influenced by both, GO content and radiation dose used during polymerization reaction. Non-Fickian diffusion mechanism was observed for the release of an anticancer drug gemcitabine from the polymer matrix. Due to mucoadhesive and antioxidant nature of the polymer, it could be applied as material for gastrointestinal drug delivery system.