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New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors.
Manetti, Dina; Garifulina, Alexandra; Bartolucci, Gianluca; Bazzicalupi, Carla; Bellucci, Cristina; Chiaramonte, Niccolò; Dei, Silvia; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Spirova, Ekaterina; Shelukhina, Irina; Teodori, Elisabetta; Varani, Katia; Tsetlin, Victor; Romanelli, Maria Novella.
Affiliation
  • Manetti D; Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
  • Garifulina A; Department of Molecular Basis of Neurosignaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Russian Academy of Sciences , Miklukho-Maklaya Street 16/10 , 117997 Moscow , Russia.
  • Bartolucci G; Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
  • Bazzicalupi C; Department of Chemistry "Ugo Schiff" , University of Florence , Via della Lastruccia 3 , 50019 Sesto Fiorentino , Italy.
  • Bellucci C; Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
  • Chiaramonte N; Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
  • Dei S; Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
  • Di Cesare Mannelli L; Department of NEUROFARBA, Section of Pharmacology and Toxicology , University of Florence , Viale G Pieraccini 6 , 50139 Firenze , Italy.
  • Ghelardini C; Department of NEUROFARBA, Section of Pharmacology and Toxicology , University of Florence , Viale G Pieraccini 6 , 50139 Firenze , Italy.
  • Gratteri P; Department of NEUROFARBA, Laboratory of Molecular Modeling Cheminformatics & QSAR , University of Firenze , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
  • Spirova E; Department of Molecular Basis of Neurosignaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Russian Academy of Sciences , Miklukho-Maklaya Street 16/10 , 117997 Moscow , Russia.
  • Shelukhina I; Department of Molecular Basis of Neurosignaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Russian Academy of Sciences , Miklukho-Maklaya Street 16/10 , 117997 Moscow , Russia.
  • Teodori E; Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
  • Varani K; Institute of Pharmacology , University of Ferrara , Via Fossato di Mortara 17-19 , 44100 Ferrara , Italy.
  • Tsetlin V; Department of Molecular Basis of Neurosignaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Russian Academy of Sciences , Miklukho-Maklaya Street 16/10 , 117997 Moscow , Russia.
  • Romanelli MN; Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Via Ugo Schiff 6 , 50019 Sesto Fiorentino , Italy.
J Med Chem ; 62(4): 1887-1901, 2019 02 28.
Article in En | MEDLINE | ID: mdl-30681854
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Receptors, Nicotinic / Nicotinic Agonists / Alpha7 Nicotinic Acetylcholine Receptor / Norbornanes Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Receptors, Nicotinic / Nicotinic Agonists / Alpha7 Nicotinic Acetylcholine Receptor / Norbornanes Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos