The Fanconi Anemia Pathway and Fertility.
Trends Genet
; 35(3): 199-214, 2019 03.
Article
in En
| MEDLINE
| ID: mdl-30683429
ABSTRACT
Fanconi anemia (FA) is a life-threatening syndrome characterized by bone marrow failure and cancer predispositions. The past two decades have seen an explosion of data in the FA field, both in humans and other organisms, following the cloning of 22 FA genes. A common but notably understudied clinical feature of the disease is the reduced fertility of individuals with FA. This review focuses on the known causes of reduced fertility in FA, and integrates them with the emerging role of the FA pathway in double-strand break (DSB) repair at meiosis in a variety of organisms, as well as providing future directions for research and diagnostics.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fanconi Anemia
/
Fertility
/
Bone Marrow Failure Disorders
Limits:
Humans
Language:
En
Journal:
Trends Genet
Journal subject:
GENETICA
Year:
2019
Document type:
Article
Affiliation country:
Australia
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM